Cefepime for serious community acquired lower respiratory infection:44 cases report
- VernacularTitle:头孢吡肟治疗社区获得性重症肺炎44例临床观察
- Author:
Zeyun ZHOU
;
Qiao ZHANG
- Publication Type:Journal Article
- Keywords:
severe community acquired lower respiratory infection;
cefepime
- From:Journal of Third Military Medical University
2003;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of cefepime in the treatment of serious community acquired lower respiratory infection. Methods Eighty-six patients of serious community acquired lower respiratory infection were randomized into the experimental group (n=44) receiving cefepime (2 g, intravenous infusion, twice a day) for 7-14 d and the control group (n=42) receiving cefotaxime (3 g, intravenous infusion, three times a day) for 7-14 d. Results There were no statistical differences of age, severity of the disease, original diseases, or distribution of pathogens between the two groups. In the experimental group, cefepime had a good therapeutic efficacy against not only the gram-negative bacteria infection and the gram-positive bacteria infection, but also other cephalosporin-resistant bacteria infection. Its cure rate was 86.4%, and effective rate 93.2%. In the control group, cefotaxime had a less therapeutic efficacy against the infection caused by some resistant strains of the gram-negative bacteria and the gram-positive bacteria. Its cure rate was 64.3%, and effective rate 76.2%. Conclusion The antibacterial activity of cefepime is stronger than that of cefotaxime. So cefepime is an effective and safe antibiotic, and suggested to use in the empirical treatment for serious community acquired lower respiratory infection.
