Correlation of COX-2 and VEGF-C expressions in breast carcinoma with lymph node metastasis
- VernacularTitle:乳腺癌组织COX-2、VEGF-C的表达与淋巴结转移的关系
- Author:
Changxiu LI
;
Youde CAO
- Publication Type:Journal Article
- Keywords:
breast neoplasma;
vascular endothelial growth factor-C;
cyclooxygenase-2;
lymphoangiogenesis
- From:Journal of Third Military Medical University
2003;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of COX-2 and VEGF-C in breast carcinoma and their correlation with lymphangiogenesis and lymph node metastasis. Methods The expressions of COX-2 and VEGF-C and D2-40 were evaluated in 46 cases of breast carcinoma by immunohistochemical staining SP methods. The lymphatic vessels density (LVD) in tumor was counted through the special marker D2-40. Results The positive rate of COX-2 and of VEGF-C was 73.91% (34/46) and 71.74% (33/46) respectively in breast carcinoma tissues. The positive rate of COX-2 and VEGF-C was 86.48% (32/37) and 81.08% (30/37), and LVD was (13.350?3.097)/?200 in the lymph node metastasis group, while that in non-lymph-node metastasis group was 22.22% (2/9), 33.33% (3/9) and (9.560?2.031)/?200 respectively, with significant difference between the two groups (P
