Pharmacokinetics of theophylline in patients with COPD and its interference factors
- VernacularTitle:慢性阻塞性肺疾病患者茶碱药动学变化及其影响因素
- Author:
Xiaoming LIU
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary diseases;
theophylline;
pharmacokinetics;
interaction;
HPLC;
UV
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). The values of k and Cl were faster and t1/2 was shorter in the middle-aged patients than those in old COPD patients (P0.05). In addition, the results showed that there was no significant change in theophylline recovery in pure serum of theophylline and mixture serum of theophylline and CTRX. CONCLUSION: The pathological state of COPD appears not to affect the pharmacokinetic profiles in middle-aged patients with COPD. It is not necessary to change the therapeutic combination with nifedipine in COPD patients. Theophylline serum concentrations determined by HPLC and UV methods are highly correlated and both can be used in the clinical pharmacokinetics study.
