Protective effects of Cyclovirobuxine D on neonatal rat cardiomyocytes exposed to hypoxia-reoxygenation injury
- VernacularTitle:环维黄杨星D对培养大鼠乳鼠心肌细胞缺氧/复氧损伤的保护作用
- Author:
Huiqin ZHANG
;
Senzhou CHEN
;
Aifang CHEN
;
Xiaojie LIU
;
Juan HOU
;
Zhiqing CUI
- Publication Type:Journal Article
- Keywords:
cyclovirobuxine D;
hypoxia/reoxygenation;
apoptosis;
caspase
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the cardioprotective effects of Cyclovirobuxine D on pure cultared neonatal rat cardiomyoeytes exposed to hypoxia-reoxygenation (H/R) injury and the mechanisms. Methods The hypoxia/reoxygenation(H/R) injury model of pure cultured neonatal rat cardiomyocytes was developed.The concentration of lactate dehydrogenase (LDH) and malonialdehvde (MDA), the activity of super-oxide dismutes (SOD) and caspase-3, the apoptosis rate of cardiomyocyte were measured.Results Compared with the control group, the model group showed lower activity of SOD and higher concentrations of LDH , MDA, the apoptosis rate and activity of caspase-3(P
