Influence of onset and duration of action on addiction potential of abused drugs
- VernacularTitle:起效时间与有效时间对药物依赖潜能的影响
- Author:
Gang YU
;
Zehui GONG
- Publication Type:Journal Article
- Keywords:
onset of action;
duration of action;
addiction
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
The addiction potential of abused drugs can be different although their pharmacodynamics characteristics are quite similar.In this article, the influence of pharmacokinetics characteristics of a drug on its addiction potential was discussed. A more rapid rate of onset had been shown to result in greater propensity to addiction. Although prolonging the duration of action could reduce the responding rate in animal self-administration experiments, it might not influence the strength of a drug. Understanding the relationship between the pharmacokinetics characteristics and addiction potential may contribute to the rational use and development of these kinds of drugs.
