Effects of progesterone on morphine-induced conditioned place preference and levels of endogenous opioid peptides in hypothalamus of rat brain
- VernacularTitle:孕酮对吗啡位置偏爱大鼠下丘脑中内阿片肽水平的影响
- Author:
Dongzhen YU
;
Honghai WU
;
Yanning HOU
- Publication Type:Journal Article
- Keywords:
progesterone;
morphine;
conditioned place preference;
hypothalamus;
endogenous opioid peptides
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of progesterone on morphine rewarding effect and levels of endogenous opioid peptides in hypothalamus of rat brain. Methods Conditioned place preference(CPP)test was used to investigate the morphine rewarding effect, and radioimmunoassay (RIA) was established to deter-mine levels of ?-endorphin(?-EP), leu-enkephalin(L-EK) and dynorphin A(DynA) in hypothalamus of rat brain.Results Compared with NS control group, 5 mg?kg-1 morphine successfully induced the formation of CPP(P
