Clinical features and the efficient therapy of 66 acute promyelocytic leukemia patients with high initial white blood cell count
- VernacularTitle:原发高白细胞型急性早幼粒细胞白血病66例临床特征及治疗研究
- Author:
Mengxing XUE
;
Huiying QIU
;
Aining SUN
- Publication Type:Journal Article
- Keywords:
Promyelocytic,leukemia,acute;
Clinical features;
Therapy
- From:
Chinese Journal of Practical Internal Medicine
2006;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features and the efficient therapy of acute promyelocytic leukemia(APL)with high initial white blood cell(WBC)count.Methods The clinical features of 66 newly diagnosed APL patients with high initial WBC and 152 patients without high initial WBC from the First Affiliated Hospital of Soochow University between October 1993 and August 2006 were retrospectively analyzed.Additionally,66 patients with high WBC were divided into different groups according to the different induction therapy and the therapeutic effects were compared.Results The early death rate and the incidence of disseminated intravascular coagulation(DIC)and retinoic acid syndrome(RAS)were 30.3%,57.6% and 31.8% respectively for the group with high initial WBC,which were higher than the indexes of 7.2%,38.1% and 21.05% respectively for the group without high initial WBC(P
