The Correlation of the D442G Polymorphism of CETP Gene with the Natural Longevity in Uygur Population
- VernacularTitle:胆固醇酯转运蛋白基因D442G多态性与维吾尔族自然长寿的关联
- Author:
Ling SUN
;
Qun XU
;
Zuheng CHENG
;
Changchun QIU
- Publication Type:Journal Article
- Keywords:
CETP;
Polymorphism;
Longevity;
Uygur population
- From:
Journal of Medical Research
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between polymorphisms within the CETP gene, D442G,and natural longevity in the Uygur population. Methods 191 healthy individuals over 90 years old and 53 control individuals who died before their 75 years were recruited. The D442G polymorphism within CETP gene was genotyped by PCR-RFLP and PCR-Sequencing. Results There were no difference in the genotypes and alleles distribution of D442G polymorphisms within the CETP gene between longevity group and control group. Conclusions There were no the correlation between the D442G polymorphisms within CETP gene and natural longevity of Uygur population in Hetian. The difference of D442G polymorphism existed in not only races, but also regions where the same race dwelled.
