Gut Protective Effect of Rhubarb and Glutamine on Intestinal Ischemia Reperfusion Rats
- VernacularTitle:大黄与谷氨酰胺对肠缺血再灌注大鼠肠道保护作用比较研究
- Author:
Jiayan SUN
;
Dingyu TAN
;
Hairong ZHU
;
Zhongfang XIA
- Publication Type:Journal Article
- Keywords:
Rhubarb;
Glutamine;
Intestinal ischemia reperfusion
- From:
Journal of Medical Research
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and compare the protective effect of rhubarb and Gln on morphology and permeability of rats intestine after SMA ischemia reperfusion.Methods 40 male rats were divided into rhubarb ,Gln, control and pseudosugery group(n=10)randomly. The intestinal I/R model of rhubarb ,Gln and control group rats was established and TPN was done.Rhubarb ,Gln and normal saline were given orally in rhubarb,Gln and control group respectively. SMA was decoherenced but not blocked in control group. Urine ,intestine,MLN and portal vein blood were collected for L/M,morphology and bacterial translocation study.Results (1)L/M was significant high in control group compared with pseudosugery group(P
