STUDY ON THE EFFECT OF CASEIN HYDROLYSATE ON HYPERTENSIVE RATS
- VernacularTitle:酪蛋白酶解产物对高血压影响的研究
- Author:
Xia GONG
;
Guiyu HAO
;
Lanfang WANG
;
Bengheng GUO
- Publication Type:Journal Article
- Keywords:
casein;
hydrolysate;
angiotensin-I-converting enzyme;
hypertension
- From:
Acta Nutrimenta Sinica
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of casein hydrolysate (CH) on hypertensive rats. Method: Hydrolysate of casein was desalinated by macroporous adsorption resins DA201C. Angiotensin converting enzyme (ACE) inhibitory activity and antihypertensive activity of casein hydrolysate at the dose of 500, 1 000 mg/kg were measured. Results: CH had significant inhibitory activity against ACE (the inhibitory rate 80.1%), and low concentration (500 mg/kg bw?d) had remarkable antihypertensive activity on spontaneously hypertensive rats (SHR), and extremely remarkable at high concentration (1 000 mg/kg bw?d). Conclusion: Casein hydrolysate showed antihypertensive activity in SHR.
