THE IMPACTS OF FOLIC ACID, RIBOFLAVIN AND MTHFR C677T POLYMORPHISM ON HUMAN LYMPHOCYTES GENOMIC STABILITY
- VernacularTitle:叶酸、核黄素及MTHFR C677T多态性对人淋巴细胞遗传稳定性的影响
- Author:
Xu WANG
;
Xiaoling XIA
;
Xiayu WU
;
Xiangxu KAN
;
Neng CAO
- Publication Type:Journal Article
- Keywords:
folic acid;
riboflavin;
MTHFR polymorphism;
cytokinesis-block micronucleus assay;
genomic stability
- From:
Acta Nutrimenta Sinica
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the comprehensive effects of folic acid (FA), riboflavin (RF) and MTHFR C677T polymorphism on genomic stability. Method: Cytokinesis-block micronucleus assay was used to detect the effects of different concentration combination of FA (20 and 200nmol/L, i.e. LF and HF) , RF (1 and 500 nmol/L, i.e. LR and HR) and MTHFR C677T polymorphism on genomic stability of 9 d cultured human lymphocytes. Results: The genetic damage was significantly higher in LFHR group regardless the genotype (P
