EFFECT OF ELEMENTAL SELENIUM AT NANO SIZE (Nano-Se) WITH LOWER TOXICITY ON THE ANTI-TUMOR EFFECT OF CISPLATIN
- VernacularTitle:低毒性的纳米硒对顺铂抗肿瘤作用的影响
- Author:
Huali WANG
;
Jinsong ZHANG
;
Hanqing YU
- Publication Type:Journal Article
- Keywords:
Nano-Se;
sodium selenite;
cisplatin;
toxicity
- From:
Acta Nutrimenta Sinica
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of Nano-Se with lower toxicity on the anti-tumor effect of cisplatin. Method: For toxicity comparison, mice were orally administered Nano-Se and sodium selenite to observe death, body weight loss and liver injury. As to the protective effect of Nano-Se on the toxicity of cisplatin, mice with and without Nano-Se supplementation were injected cisplatin to observe death and body weight loss. For evaluation of whether Nano-Se influence the anti-tumor effect of cisplatin, Lewis lung carcinoma was transplanted into mice, and the survivor and tumor volume were recorded to compare the effect of Nano-Se supplementation on cisplatin. Results: The toxicity of Nano-Se is significantly lower than sodium selenite. Nano-Se can decrease toxicity of cisplatin without compromising its anti-tumor effect. Conclusion: Nano-Se with lower toxicity can improve the therapeutic effect of cisplatin.
