THE PREVENTIVE AND THERAPEUTIC EFFECTS OF SILK FIBROIN ACTIVE PEPTIDES ON ACUTE ALCOHOLISM IN MICE
- VernacularTitle:丝素活性肽对小鼠急性酒精中毒的防治作用研究
- Author:
Fengjuan ZHOU
;
Shiying XU
;
Ruijin YANG
;
Zhang WANG
- Publication Type:Journal Article
- Keywords:
silk fibroin active peptides;
alcoholism
- From:
Acta Nutrimenta Sinica
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the preventive and therapeutic effects of silk fibroin peptides (SFP) on acute alcoholism in mice. Methods:In first experiment, the mice were randomly divided into four groups, and every group was treated by 56o alcohol (ethanol dosage 7.56 ml/kg bw) via i.g. Eighty mice were fed normal saline (NS) and different dosages of SFP (0.1, 0.5, 2.5 g/kg bw) 30 min later respectively, then the rate of ebriety and time of sobriety were determined. Another 72 mice were also divided into four groups and given NS and SFP similarly. The concentration of ethanol in serum was measured 1 h, 2 h and 4 h later respectively. In second experiment, the mice were also divided into four similar groups, but 56o alcohol was given at 6.16 ml/kg?bw via i.g. NS and SFP were given similarly, 0.5 h before alcohol. Two experiments were performed to observe the effect of SFP on prevention of temulence. Results:The time of sobriety and concentration of ethanol of SFP groups fed 0.5 and 2.5g/kg bw were lower significantly than those of NS group (P
