Relationship of interleukin-6 gene polymorphisms and its serum level with essential hypertension
- VernacularTitle:白细胞介素-6基因多态性及血清水平与原发性高血压的关系
- Author:
Haixia FU
;
Jiaying ZHANG
;
Ziniu ZHAO
;
Gengshan LI
- Publication Type:Journal Article
- Keywords:
hypertension;
interleukin-6;
gene;
polymorphisms
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of interleukin-6 (IL-6) gene polymorphisms and its serum level with essential hypertension (EH) in Chinese Hans population and investigate the effect of IL-6 gene polymorphisms on serum IL-6 level. Methods The polymorphisms of IL-6 gene, -597 G/A, - 572 C/G and 174 G/C, were checked in 191 EH patients and 197 control subjects by PCR-RELP. Meanwhile their serum IL-6 level was determined by ELISA. Results Only -597 GG genotype and -174 GG genotype of IL-6 gene was found in the test population. There was significant difference in frequencies of - 572 genotype and allele between 2 groups. -572 CG+GG genotype and G allele were more frequent in patients than in controls (P
