Relationship of PTTG, bFGF, P53 expressions with invasiveness of pituitary adenoma
- VernacularTitle:PTTG、bFGF和P53的表达与垂体腺瘤侵袭性的关系
- Author:
Silong LOU
;
Gang HUO
;
Luping ZHENG
;
Qinbi DAI
- Publication Type:Journal Article
- Keywords:
pituitary adenomas;
invasiveness;
hPTTG;
bFGF;
P53
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between mRNA and protein expressions of PTTG, bFGF, P53 with tumorigenesis and invasiveness of pituitary adenoma. Methods The protein expressions of PTTG, bFGF, P53 were detected by immunohistochemical analysis, and their mRNA expressions were by reverse transcription polymerase chain reaction (RT-PCR) in 63 specimens of pituitary adenoma that was classified into invasive and non-invasive according to Wilson’s modified staging. Results Thirty-four specimens of pituitary adenoma were invasive and 29 non-invasive. The expressions of PTTG, bFGF, P53 were significantly higher in invasive pituitary adenoma than in non-invasive. The analysis of correlation showed that in invasive pituitary adenoma, the positive correlation exists between PTTG and bFGF mRNA (r=0.81, P
