Effect of mistletoe lectins on proliferation and apoptosis in HT-29 colon cancer cell
- VernacularTitle:槲寄生凝集素对人结肠癌HT-29细胞增殖及凋亡的影响
- Author:
Shaomin WANG
;
Meng YE
;
Shuming NI
- Publication Type:Journal Article
- Keywords:
mistletoe lectins;
colon cancer;
apoptosis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the effect of mistletoe lectins on cell proliferation and apoptosis in HT-29 human colon cancer cell.METHODS:The effect of mistletoe lectins on cell viability in HT-29 cell was evaluated by MTT assay.Cell apoptosis was observed by DNA ladder analysis and Tunel.RESULTS:Mistletoe lectins(eg.,1-4 mg/L) inhibited cell growth in a dose and time dependent way in HT-29 cells.HT-29 cells apoptosis can be induced when exposed to mistletoe lectins(eg.,1-4 mg/L).CONCLUSION:Mistletoe lectins can inhibits proliferation and induces apoptosis in HT-29 cells in vitro.
