Protective effects and mechanism of Guanxinkang capsules on myocardial injury induced by isoproterenol in rats
- VernacularTitle:冠心康胶囊对实验性急性心肌缺血大鼠心肌损伤的保护作用及机制
- Author:
Zhi PAN
;
Fujin DUAN
;
Xionghui WEI
- Publication Type:Journal Article
- Keywords:
Guanxinkang capsules;
acute myocardial ischemia;
myocardium injury
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects and mechanism of Guanxinkang capsules on myocardial injury induced by isoproterenol in rats.Methods 30 male Wistar rats were randomly divided into 3 groups:control group,acute myocardial ischemia group and Guanxinkang capsules group.Rats were given injections of ISO subcutaneously.Electrocardiography were performed,serum and myocardium creatine kinase(CK),creatine kinase MBmass(CK-MB),lactate dehydrogenase(LDH) and nitric oxide(NO) were detected,and the levels of NO and endothelins(ET) in myocardium were measured as well.Results The rising degree of ST-T obviously decreased in Guanxinkang capsules group,and the levels of serum CK,CK-MB and LDH decreased in Guanxinkang capsules group,compared with those of acute myocardial ischemia group(P
