Relaxin and cardiovascular fibrosis
- VernacularTitle:松弛素和心血管纤维化
- Author:
Ping WANG
;
Sanqing JIA
;
Chaoshu TANG
- Publication Type:Journal Article
- Keywords:
relaxin;
cardiovascular;
fibrosis
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular fibrosis is the common pathological manifestation of many heart diseases.Relaxin inhibits fibrosis through several mechanisms as follows relaxin inhibits fibroblast function,collagen synthesis/secretion and the influence of several profibrotic factors.Relaxin stimulates MMP expression.Relaxin rapidly inhibits cardiovascular fibrosis and has no effect on normal tissue.It is a potential and selective antifibrotic target of cardiovascular diseases.
