Effects of bradykinin on the expression of interleukin-1? in C6 glioma cells
- VernacularTitle:缓激肽对C6胶质瘤细胞IL-1?表达的影响
- Author:
Zhenhua WANG
;
Yixue XUE
- Publication Type:Journal Article
- Keywords:
glioma;
bradykinin;
interleukin-1?;
blood tumor barrier
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of bradykinin on the expression of IL-1? in C6 glioma cells and provide an experimental basis for the mechanism of bradykinin opening the blood tumor barrier.Methods Semi-quantitive RT-PCR and radioimmunoassay were used to detect the expression of IL-1?mRNA in C6 glioma cells and the content of IL-1? in the culture media treated with bradykinin respectively.Results RT-PCR revealed that the expression of IL-1?mRNA was significantly elevated with bradykinin treated for 15min(P
