Effects of Duxil on striatum extracellular acetylcholine,glucose and lactic acid levels in rats of cerebral energy metabolism impairment
- VernacularTitle:都可喜对脑能量代谢障碍大鼠纹状体细胞外液乙酰胆碱、葡萄糖和乳酸水平的影响
- Author:
Wei WANG
;
Danqiao WANG
;
Chunyu CAO
;
Dezhong ZHAO
- Publication Type:Journal Article
- Keywords:
sodium azide;
acetylcholine;
glucose;
lactic acid;
microdialysis;
energy metabolism
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of masculine drug Duxil on striatum extracellular acetylcholine(ACh),glucose and lactic acid(LD) levels in energy metabolism impairment rats induced by intracerebral perfusion with sodium azide(NaN3).Methods Rats were divided into three groups:control,model and Duxil groups.Rats of Duxil group were treated with 10 mg?kg-1?d-1 Duxil for 14 d.Other two groups were treated with water for 14 d.After 2 wk microdialysis technique was adopted and the rats were perfused with NaN3 in striatum and continuously measured striatum extracellular ACh,glucose and LD levels in freely moving awake rats.Results During perfusion(90 min) and stoping perfusion(180,240,360 min)period with NaN3 striatum extracellular ACh levels in the model group were significantly lower than those in the control group(P
