Effect of rosiglitazone on expression and excretion of connective tissue growth factor in renal tissue and urinary of diabetic rats
- VernacularTitle:罗格列酮对糖尿病大鼠肾脏结缔组织生长因子表达和排泄的影响
- Author:
Wei CHEN
;
Shandong YE
;
Yingxin WANG
;
Wen HU
;
Aihong FAN
;
Yan CHEN
;
Guangwei YANG
;
Xiucai LI
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
connective tissue growth factor;
rosiglitazone
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effect of rosiglitazone(RGZ)on expression and excretion of connective tissue growth factor(CTGF) in renal tissue and urinary of diabetic nephropathy rats.Methods Three groups of rats were studied:normal control group(n=8),STZ-induced diabetic model group(n=8),diabetes RGZ-treatment group(n=8).Urinary CTGF was measured at the 1 st,4 th,6 th and 8 th week,as well as the expressions of CTGF protein(by histochemical staining)at the 8 th week by ELISA.Results The urinary excretion rates of CTGF at 4 th、6 th、8 th weeks and the expressions of CTGF protein in renal cortex at 8th weeks significantly increased in STZ-induced model group compared with those in normal group(P
