Influence of sulfonylureas on cardiovascular system:progress in basic research and clinical research
- VernacularTitle:磺脲类药物对心血管系统影响的基础和临床研究进展
- Author:
Guoliang JIANG
;
Guoting WU
- Publication Type:Journal Article
- Keywords:
sulfonylureas;
ATP-sensitive K+ channels;
peroxisome proliferator-activated receptors;
cardiovascular disease
- From:
Academic Journal of Second Military Medical University
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Previous studies have showed that sulfonylureas possess a bidirectional effect on cardiovascular system:they can raise the coronary artery tone,aggravate ischemic injury to the cardiovascular tissues,and accelerate cardiac hypertrophy through closing cardiovascular ATP-sensitive K+ channels;meanwhile,they can also regulate glucolipid metabolism,modulate inflammatory reaction and inhibit atherosclerosis through activating peroxisome proliferator-activated receptors.Clinical-epidemiological study showed different opinions on whether sulfonylureas can increase the mortality of patients with cardiovascular diseases.
