Vitamin E Succinate inhibits growth and induces apoptosis of prostate cancer cell line PC-3
- VernacularTitle:维生素E琥珀酸酯对前列腺癌PC-3细胞株的生长抑制和诱导凋亡作用
- Author:
Lihang YU
;
Bo YANG
;
Linhui WANG
;
Yinghao SUN
- Publication Type:Journal Article
- Keywords:
vitamin E succinate;
prostatic neoplasms;
apoptosis
- From:
Academic Journal of Second Military Medical University
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the inhibitory and apoptosisinducing effect of vitamin E succinate(VES) on androgen-independent prostate cancer cell line PC-3 in vitro.Methods: VES was dissolved with ethanol to obtain VES solution.PC-3 cells of logarithmic growth phase were treated with various concentrations of VES solution(25,50,75,100,and 125mg/L);cells in control group were treated with 1.25% ethanol.MTT method was used to measure the viability and inhibitory rate of cells in each group 24h,48h and 72h after VES treatment;flow cytometry was employed to determine the apoptosis rate of the PC-3 cells.Results: The viability of cells in the experimental groups was significantly lower than that in the control group(P
