Hemodynamics and morphology of common carotid artery in pig model of obstructive sleep apnea-hypopnea syndrome
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征模型猪颈总动脉血流动力学及组织学观察
- Author:
Ye XU
;
Yongyi LIU
;
Xiang SHEN
;
Linhui JIANG
;
Zhihui YANG
;
Yinxia LIU
;
Lu GAO
- Publication Type:Journal Article
- Keywords:
sleep apnea,obstructive;
carotid artery,common;
hemodynamics;
pathology
- From:
Academic Journal of Second Military Medical University
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare a pig model of obstructive sleep apnea-hypopnea syndrome(OSAHS) and to observe the hemodynamics and pathological characteristics of common carotid artery,so as to lay a foundation for further studying the effect of OSAHS on cardiovascular system.Methods: Twelve male small-type pigs were randomly divided into model group and control group(n=6).Animals in the model group were housed in a negative pressure chamber for 6 months to establish OSAHS model and those in the normal control group were fed routinely.After pigs in the model group presented the symptoms of OSAHS,the changes in hemodynamics of carotid artery were detected with color Doppler ultrasound.The morphological changes of common carotid artery were analyzed under light microscope and electron microscope.Results: Animal model of OSAHS was successfully created.The internal diameter of carotid artery of pigs in the model group was decreased,the intima was increased,and the peak-systolic mean velocity(S) and the resistance index(RI) were both increased compared with those of the control group(P
