Effect of Itraconazole/IFN-gamma on IFN-gamma and IL-10 in Nude Mice and Mice
- VernacularTitle:伊曲康唑和?-干扰素对裸小鼠、昆明种小鼠外周血IFN-?、IL-10的影响
- Author:
Zhidong WANG
;
Wanqing LIAO
;
Hong XU
;
Wenzhao TAO
- Publication Type:Journal Article
- Keywords:
IFN-gamma;
IL-10;
Candida albicans;
Cryptococcus neoformans;
Itraconazole
- From:
Journal of Medical Research
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of itraconazole/IFN-gamma on IFN-? and IL-10 in nude mice and mice and clinical significance. Methods Systemic infection of animals that induced by abdominal injection of Candida albicans and Cryptococcus neoformans, Expression of IFN-? and IL-10 were detected by enzyme-linked immunosorbent assay (ELISA).Results After treated with Itraconazole and IFN-gamma, the levels of IFN-gamma were increased and ones of IL-10 were decreased significantly. Conclusions Itraconazole and IFN-gamma may play key roles in the immune function of those animals.
