Study of the relationship between plasma homocysteine thiolactone concentrations and type 2 diabetic macrovascular complications
- VernacularTitle:同型半胱氨酸硫内酯与2型糖尿病大血管病变的相关性研究
- Author:
Weijun GU
;
Juming LU
;
Guoqing YANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,Non-insulin-dependent;
Homocysteine thiolactone;
Vasculopathy;
homocysteine
- From:
Chinese Journal of Practical Internal Medicine
2006;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of homocysteine(Hcy)and homocysteine thiolactone(HcyT)in the development of macrovascular complications in patients with type 2 DM.Methods A total of 160 subjects were recruited in this study:40 healthy controls,120 with type 2 DM.Plasma Hcy levels were measured by Polarization Immunoassay(FPIA),and HcyT concentrations were monitored using high-performance liquid chromatography(HPLC)on a reversephase C18 column with ultraviolet detection.Plasma folic acid and Vitamin B12 levels were measured with radioimmunoassay method.Results Plasma Hcy and HcyT concentrations in type 2 DM patients were significantly higher than healthy controls[Hcy:9.28(7.51～11.82)?mol/L vs 5.64(5.17～8.00)?mol/L,P
