Significance of bFGF,FGFR-2 and Hpa expression in gastric precancerous lesions and gastric carcinoma tissues
- VernacularTitle:胃癌及癌前病变中bFGF FGFR-2及Hpa的表达及其意义
- Author:
Shanyu QIN
;
Haixing JIANG
;
Xin LI
- Publication Type:Journal Article
- Keywords:
Gastric neoplasms;
Basic fibroblast growth factor;
Fibroblast growth factor receptors-2;
Heparanase
- From:
Chinese Journal of Practical Internal Medicine
2006;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of basic fibroblast growth factor(bFGF),fibroblast growth factor receptor-2(FGFR-2)and heparanase(Hpa)in the tissues of gastric cancer and precancerous lesions,and to explore its significance in the carcinogenesis and malignant progression of stomach.Methods The expression of bFGF,FGFR-2 and Hpa were detected by immunohistochemistry in 145 cases of paraffin-embedded specimens from different gastric mucosa,including 30 cases of chronic superficial gastritis(CSG),29 of intestinal metaplasia(IM),31 of dysplasia(Dys)and 55 of gastric carcinoma(GC).Results The expression of bFGF and FGFR-2 in CSG group was significantly lower than that of the other three groups(P
