Effect of a novel isoflavone compound on plasma lipid and cholesterol of ovarectomied rats
- VernacularTitle:新型异黄酮类化合物对去势大鼠血脂胆固醇的影响
- Author:
Xiuming CHEN
;
Guoping AI
;
Yongping SU
;
Lilong ZHANG
;
Qing CHANG
- Publication Type:Journal Article
- Keywords:
ovarectomy;
animal model;
plasma lipid;
body weight
- From:Journal of Third Military Medical University
2003;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of a novel isoflavone compound(F11) on the plasma lipid and cholesterol of the ovarectomied rat.Methods Female SD rats at age of 3 months old were randomly divided into 6 groups,that is,sham operation group(Sham),normal saline group(2 ml/d),estradiol group(E2,50 ?g?kg-1?d-1),and 3 F11 groups(15,50,150 mg?kg-1?d-1).Besides the Sham group,the ovary of the rats from other groups were resected,and received the injection as above mentioned.All rats were killed 10 weeks later,and their plasma lipid,total cholesterol,LDL,HDL,and body weight and uterine weight were measured.Results The plasma lipid,total cholesterol,LDL,HDL were significantly different in normal saline group and 4 treatment group(P
