Effect of melatonin on GAD67 mRNA expression in post-SE rat hippocampus induced by pilocarpine
- VernacularTitle:褪黑素对癫痫状态大鼠海马GAD67 mRNA表达的影响
- Author:
Yingqi ZHANG
;
Weihong LIAO
;
Zaiyun LONG
- Publication Type:Journal Article
- Keywords:
status epilepticus;
hippocampus;
melatonin;
?-aminobutyric acid;
glutamin acid decarboxylase
- From:Journal of Third Military Medical University
2003;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To probe the mechanism of anticonvulsant by melatonin from the angle of neurotransmitter.Methods Rat status epilepticus(SE) model was induced by pilocarpine(PILO).?-aminobutyric acid(GABA) content and glutamin acid decarboxylase(GAD)67 mRNA expression was detected at 6,48,72 h,and 7 d in the hippocampus of post-SE rats.The effect of melatonin on these changes was observed.Results GABA content was significantly lower in the hippocampus than in control(P
