Study on anti-tumor mechanism of Chinese medicine Fuzhengyiliufufang by molecular docking method
- VernacularTitle:用分子对接法探讨扶正抑瘤复方制剂的抑瘤作用机制
- Author:
Chunsong ZHENG
;
Liwu CHEN
;
Jian DU
;
Hongzhi YE
- Publication Type:Journal Article
- Keywords:
Chinese herbal medicine;
plant preparations;
molecular docking;
IL-2;
TNF-?;
cancer
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the anti-tumor effects of Chinese medicine Fuzhengyiliufufang(FZYLFF) and its mechanism.METHODS:Molecular docking was apllied to simulate the interactions between Chinese medicine small molecules and TNF-?,IL-2 receptors respectively,with the aid of ligand-fit module in the software package Cerius2 4.10 of Accelrys company,to predict the effects of FZYLFF on anti-tumor.RESULTS:According to the dockscore of original ligand and the receptor as threshold value,thirty-seven molecules were predicted to have good interactions with TNF-? and ten molecules with IL-2.CONCLUSION:FZYLFF is a promising Chinese medicine for tumor therapy.Its mechanism is possibly attributed to indirect inhibition by interfering inflammatory cell factors and enhancing immunoregulation.
