Effect of atorvastatin on function of carotid artery after adventitia removal in spontaneously hypertensive rats
- VernacularTitle:阿托伐他汀对自发性高血压大鼠去外膜颈动脉血管功能的影响
- Author:
Hao YANG
;
Ming WU
;
Junyuan WANG
;
Ancai WANG
- Publication Type:Journal Article
- Keywords:
atorvastatin;
spontaneously hypertensive rats;
carotid artery;
adventitia;
vascular remodeling;
vascular resistance
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the effect of atorvastatin on the function of carotid artery after adventitia removal in SHR.METHODS:16-week old male SHR(n=36) with left carotid artery adventitia removed were randomly divided into 3 groups(n=12,each):SHR control group,atorvastatin group,valsartan group and the half rats of each group were put to death at the 4th and 8th weeks respectively.The systolic blood pressure(SBP) was assessed before and after treatment with atorvastatin every 2 weeks.The velocity of carotid artery was detected by electromagnetic rheometer while vasotension changes to NE was measured using a force transducer connected with a polygraph.RESULTS:Compared with SHR control group,the SBP of atorvastatin group began declining at the 4th week,and was reduced significantly at the 6th and 8th weeks(P0.05).Vasotension to NE of carotid artery was reduced significantly after adventitia removal(P
