Involvement of volume-regulated Cl~- current in myocardial hypertrophy
- VernacularTitle:容积调节性Cl~-电流在心肌肥厚时电重构中的作用
- Author:
Liang HONG
;
Guanlei WANG
;
Yongyuan GUAN
- Publication Type:Journal Article
- Keywords:
myocardial hypertrophy;
electrical remodeling;
volume-regulated Cl-current
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial hypertrophy is the complication of many cardiovascular diseases that induce cardiac remodeling.The molecular mechanism of cardiac remodeling involves abnormal changes in various transmembrane ionic currents in the heart.Recent studies suggest the potential involvement of volume-regulated Cl-current(ICl.Vol)in cardiac hypertrophy.Although the molecular basis of ICl.Vol remains to be elucidated,recent progress is reviewed in the potential role of ICl.Vol in cardiac remodeling.
