Advances in study of common targets of myocardial ischemic preconditioning and postconditioning during reperfusion
- VernacularTitle:心肌缺血预适应及后适应在再灌注期共同靶点的研究进展
- Author:
Yanna WU
;
Jianshi LOU
- Publication Type:Journal Article
- Keywords:
reperfusion;
preconditioning;
postconditioning;
mechanism
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
As a powerful endogenous protection,myocardial ischemic preconditioning and postconditioning have cardioprotection against ischemia reperfusion injury and cardiopretection against reperfusion injury respectively.They perhaps share some mechanisms during reperfusion,such as reduction of the production of oxygen free radical,activation of adenosine receptors,recruit of reperfusion injury salvage kinases,opening of the mitochondrial KATP channel,and inhibition of the mitochondrial permeability transition pore.These common targets may provide new strategy for development of drugs against reperfusion injury.
