Benazepril and candesartan on expressions of SMADs during myocardial hypertrophy in spontaneous hypertensive rats
- VernacularTitle:苯那普利及坎地沙坦对自发性高血压大鼠心肌肥厚过程中SMAD蛋白的影响
- Author:
Jiliang XU
;
Guoliang MENG
;
Liyun YANG
;
Yali REN
;
Jue YU
- Publication Type:Journal Article
- Keywords:
myocardial hypertrophy;
transforming growth factor;
SMAD;
angiotensin Ⅱ;
benazepril;
candesartan;
spontaneous hypertensive rats
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the myocardial hypertrophy,the expression of transforming growth factor ?1(TGF-?1),Smad3 and Smad7 proteins in spontaneous hypertensive rats(SHR)and the effects of benazepril and candesartan.Methods SHRs of 12 weeks old were given benazepril and candesartan for 12 weeks.The tail arterial pressure was measured every two weeks.At 12 th weekend,cardiac configuration,heart mass index,area of cadiocytes,concertrations of AngⅡin plasma and myocardium,expressions of TGF-?1、Smad3 and Smad7 proteins were measured respectively.Results The arterial pressure,wall thickness,heart mass index,area of cardiocytes and the expressions of TGF-?1,Smad3 proteins increased in SHRs but were attenuated after the treatment of benazepril or candesartan.After the combined treatment,the synergistic effect could be observed.The levels of cardiac tissue and plasma AngⅡwere reduced.The expressions of Smad 7 were up-regulated after the treatment of benazepril or candesartan,while they were stable after the combined use.Conclusion There is a synergistic effect of attenuating myocardial hypertrophy in SHRs by combined use of benazepril and candesartan.It may be related to the regulation of Ang Ⅱ,decreasing the expressions of TGF-?1 and Smad3.
