Effects of GCIP-27 on the structure of left ventricle in spontaneously hypertensive rats
- VernacularTitle:GCIP-27对自发性高血压大鼠左心室结构影响的实验研究
- Author:
Xiuqin WANG
;
Xiaohui LI
;
Haigang ZHANG
;
Yiqun CHENG
- Publication Type:Journal Article
- Keywords:
peptides drug;
hypertension;
myocardium remodeling
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effects of GCIP-27(G protein competitive inhibitory polypeptide-27) on the structure of left ventricle in spontaneously hypertensive rats(SHR).Methods Thirty SHR rats of 12 weeks old were randomly divided into five groups(n=6):blank control groups,GCIP-27(10,30,90 ?g?kg-1,ip,bid)groups,and Losartan group(6 mg?kg-1),six Wistar-Kyotos(WKY) rats were as normal control.Systolic blood pressure(SBP)was measured once per two weeks with tail-sleeve methods.At the end of the 8th week,left ventricle weight index(LVWI)were determined.Myocardium structure was observed by polaroscope and transmission electron microscope.The area and content of myocardial interstitial collagen were treated for semiquantitative analysis by image analyzer system.Results The SBP in GCIP-27(10,30,90 ?g?kg-1)groups decreased significantly from the 2 nd to the 8th week by comparison with blank control group.GCIP-27(10,30,90 ?g?kg-1) lowered heart mass index(HMI)and left ventricular mass index(LVMI)markedly compared with blank control group(P
