Effect of NGF on tau hyperphosphorylation in rat hippocampus during focal cerebral ischemia-reperfusion
- VernacularTitle:NGF对局灶性脑缺血/再灌注大鼠海马tau蛋白磷酸化作用的影响
- Author:
Zhenghong ZHANG
;
Gangming XI
;
Wenchun LI
;
Peng QU
;
Xiubin FANG
- Publication Type:Journal Article
- Keywords:
nerve growth factor;
cerebral ischemia;
tau protein;
phosphorylation;
rats
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effect of exogenous nerve growth factor(NGF) on tau hyperphosphorylation in rat hippocampus during focal cerebral ischemia/reperfusion(I/R).Methods Focal cerebral ischemi-a/reperfusion model was induced by occlusion of the right middle cerebral artery using the intraluminal suture method.The level of tau hyperphosphorylation at Ser199/202 site and total tau in rat ispolateral hippocampal CA1 regions during focal cerebral ischemia/reperfusion were detected by SABC immunohistochemical method and Western blot,and the positive products were analyzed by image analysis system.Results The level of tau hyperphosphorylation at Ser199/202 site and total tau in rat hippocampal CA1 regions were significantly higher in I/R group than that in sham group(P
