Clinical significance of airway hyperresponsiveness and inflammatory markers in induced sputum in patients with asthma during their remission period
- VernacularTitle:缓解期哮喘患者气道反应性和诱导痰炎性标志物测定的临床意义
- Author:
Jing BAI
;
Guqin ZHANG
;
Suping HU
- Publication Type:Journal Article
- Keywords:
Asthma;
Airway hyperresponsiveness;
Eosinophils;
Eosinophil cationic protein;
Sputum
- From:
Chinese Journal of Practical Internal Medicine
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of airway hyperresponsiveness and eosinophil(Eos)percentage and level of eosinophil cationic protein(ECP)in induced sputum in patients with asthma during their remission period.Methods Seventy-six patients with asthma during their remission period were selected.Bronchial challenge test was performed and the percentage of Eos and level of ECP in induced sputum were measured by Wrights' stain and Immuno-CAP System,respectively.Thirty patients with asthma during their exacerbation period and twenty healthy subjects were selected as controls.Results In seventy-six patients with asthma during their remission period,sixty-five(85.5%)showed positive bronchial challenge test and eleven(14.5%)patients showed negative bronchial challenge test.The percentage of Eos and level of ECP in induced sputum in patients with asthma during their remission period were 0.071?0.032 and 131.5 ?g/L respectively;those in asthma group during their exacerbation period and healthy group were 0.198?0.103 vs 0.013?0.007 and 355.3 ?g/L vs 48.0 ?g/L,respectively.There was significant difference in the percentage of Eos and level of ECP in induced sputum between three groups(P
