Association of ACE gene polymorphisms with the carotid intima-media thickness in type 2 diabetes
- VernacularTitle:ACE基因多态性与新诊断2型糖尿病患者颈总动脉内中膜增厚的关系研究
- Author:
Weikun CHEN
;
Weicheng PENG
;
Yuhua LIU
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Carotid intima-media thickness;
Gene polymorphism;
Angiotensin 1-converting enzyme gene
- From:
Chinese Journal of Practical Internal Medicine
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between angiotensin 1-converting enzyme(ACE)inserting/defaulting(I/D)gene polymorphisms and the carotid intima-media thickness(CCA-IMT)in patients with type 2 diabetes(T2DM).Methods The polymorphisms of ACE(I/D)was determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)method and the CCA-IMT was assessed using non-invasive high resolution B-mode ultrasonography in 120 T2DM in Han's population of Dongguan city.The data were analyzed by Logistic regression to explore the independent and significant risk factors for CCA-IMT increase in type 2 diabetic patients.Results The DD genotype were significantly more common in diabetic patients with CCA-IMT increase than in those without it(F=10.164,P=0.006);Logistic regression analysis showed that DD genotype,age,male gender and essential hypertension contributed significantly to the CCA-IMT increase in type 2 diabetic patients(OR=3.689,1.054,1.562,respectively,P
