EFFECT OF CALCIUM ON THE EXPRESSION OF OSTEOCALCIN, PARATHORMONE AND PARATHORMONE RECEPTOR IN RAT EXPOSED TO LEAD
- VernacularTitle:钙对染铅大鼠骨钙素、甲状旁腺激素及其受体表达的影响
- Author:
Xueqin HU
;
Mantian MI
- Publication Type:Journal Article
- Keywords:
calcium;
lead;
osteocalcin;
parathormone;
parathormone receptor
- From:
Acta Nutrimenta Sinica
1956;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of calcium on osteocalcin(OC) and parathyroid hormone (PTH) in rat exposed to lead. Method: Wistar rats were randomly divided into control group, lead group, low-calcium+lead group and high-calcium+lead group. The content of calcium and lead in bone, OC and PTH of rat with different treatments were detected. At the same time, RT-PCR analysis was used to determine the expression of OC and PTHr1. Results: Lead decreased the content of calcium in bone and OC. The expression of OC was inhibited, and the level of PTH and the expression of PTHr1 increased, which could be enhanced by low calcium treatment, but high calcium treatment could antagonize these effects of lead. Conclusion: Supplementation of calcium in diet could extenuate the toxicity of lead on bone in rat.
