Effects of indole-3-carbinol on neointimal hyperplasia of rat artery after balloon injury
- VernacularTitle:吲哚-3-甲醇对大鼠动脉损伤后内膜增殖的影响
- Author:
Yonghong JIANG
;
Jing HUANG
;
Changming DENG
;
Dichuan LIU
- Publication Type:Journal Article
- Keywords:
indole-3-carbinol;
cells,smooth muscle;
proliferation;
apoptosis
- From:Journal of Third Military Medical University
2003;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of indole-3-carbinol on neointimal hyperplasia and restenosis of rat artery after balloon injury and the possible mechanisms.Methods Balloon dilation was used to establish the neointimal injury model of left carotid artery in rats.Twenty Sprague-Dawley rats were randomly divided into single balloon dilation group(control group)and balloon dilation followed by indole-3-carbinol therapy group(therapeutic group).After balloon dilation,indole-3-carbinol(12.5,25,50 mg/d)was applied to the rats for 7 days respectively.The rats were killed two weeks after balloon dilation and the injured vascular specimens were harvested for pathologic examination and immunohistochemical staining.Results ①The neointimal thickness,neointimal area in the therapeutic groups were significantly less than that of the control group(P
