Effects of electroshock on interferon gamma receptor expression in hippocampus of depressed rats
- VernacularTitle:不同电休克方法对抑郁模型大鼠海马干扰素-?受体表达的影响
- Author:
Daqi LI
;
Li KUANG
;
Minjian WANG
- Publication Type:Journal Article
- Keywords:
depression;
hippocampus;
electroshock;
interferon gamma
- From:Journal of Third Military Medical University
2003;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of interferon gamma receptor on neuron and astrocyte of the hippocampus of depressed rats.Methods The depressed rats were produced by separation raise and unpredictable mild stressors.Their behaviors were evaluated in open-field test.The rats underwent electro-convulsive treatment(ECT)or modified electric convulsive therapy(MECT).The expression of interferon gamma receptor on neuron and astrocyte of the hippocampus was detected by immunofluorescence and in situ hybridization.Results There were significant differences among the stress plus ECT group,the stress plus MECT group,the stress plus sham electroshock group in all the three tests.Conclusion ECT and MECT can both reduce the expression of interferon gamma receptor on neuron and astrocyte of the hippocampus of depressed rats,and MECT shows more stronger therapeutic effect.Cytokine may play an important role in the pathophysiologic mechanism of depression.
