Effect of GFW on the Fas Protein Expression in the S_(180) Bearing Tumor Mice
- VernacularTitle:桂枝茯苓丸对荷瘤鼠Fas表达的影响
- Author:
Qi WANG
;
Jie GUAN
;
Lili QIAN
;
Xiaoqing LUO
- Publication Type:Journal Article
- Keywords:
GFW;
T-lymphocyte;
Fas;
The flow cytometry
- From:
Journal of Medical Research
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the antitumor effects and the effect of GFW on the Fas expression in spleen T-lymphocyte of the tumor-bearing mice.Methods The S180 mice sarooma model was used to detective the inhibiting effects of GFW,the Fas expression in spleen T-lymphocyte between the normal group,the model group,the GFW group and the CY group were analyzed by the flow cytometry.Results For S180 sarcoma,the inhibiting ratio of GFW is 38.93%.The protein expression of Fas showed to rise in the the model group and the CY group.There was significant difference between them and normal group(P0.05).Conclusions GFW has the antitumor function and can adjust immune through inhibitor the apoptosis of T-lymphocyte.its mechanism maybe closely related with adjusting expression levels of the Fas expression in spleen T-lymphocyte to normal.
