Effects of PNS on the Apoptosis and Expression of C-myc of Vascular Smooth muscle Cells
- VernacularTitle:三七总皂甙对血管平滑肌细胞凋亡及C-myc基因表达的影响
- Author:
Yanbin ZHANG
- Publication Type:Journal Article
- Keywords:
Panax notoginseng saponins(PNS);
Vascular smooth muscle cells(VSMC);
Apoptosis;
C-myc
- From:
Journal of Medical Research
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of panax notoginseng saponins on the apoptosis and expression of C-myc of vascular VSMC in vitro.Methods VSMC derived from rabbit aorta were cultured in vitro and different concentrations of PNS were added in experimental groups.VSMC apoptosis was evaluated with cell ultrastructure under electron microscopy and flow cytometry.Expression of C-myc was observing by immunocytochemical method.Results The ratio of apoptosis and the expression of C-myc in PNS groups were high than control group.Conclusions PNS can increase the ratio of VSMC apoptosis which may be related the expression promoting of C-myc.
