Expression and Significance of Interleukin-18 (IL-18) and Cyclooxygenase 2 (COX-2) in Endometriosis
- VernacularTitle:IL-18、COX-2在子宫内膜异位症中的表达及意义
- Author:
Qiaoyun ZHAO
;
Shengyong LUO
- Publication Type:Journal Article
- Keywords:
Endometriosis;
Interleukin-18;
Cyclooxygenase2;
Enzyme linked immunosorbent assay;
Innunohistochemistry
- From:
Journal of Medical Research
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the Expression of interleukin-18(IL-18)and cyclooxygenase2(COX-2)in endometriosis.Methods Enzyme linked immunosorbent assay and innunohistochemistry were used to detrermine the levels of interleukin-18 in peritoneal fluid and serum,the expression difference of cyclooxygenase2 in ectopic endometrium with endometriosis and the normal control.Results The levels of interleukin-18 in peritoneal fluid and serum were higher than that of normal control,the expression of cyclooxygenase2 in ectopic endometrium with endometriosis were higher than that of normal control,and the degree in stage of Ⅲ、Ⅳ were higher than those in stage of Ⅰ、Ⅱ.Conclusions IL-18 and COX-2 is related to the endometriosis,the further studying of IL-18 and COX-2 may be helpful in the diagnosis and treatment of this disease.
