Research on the curative effect of cerebrospinal fluid replacement combining intravenous drips and intrathecal injection of amphotericin B in the treatment of cryptococcal neoformans meningitis
- VernacularTitle:脑脊液置换加静脉及鞘内注射两性霉素B治疗新型隐球菌性脑膜炎疗效研究
- Author:
Guoguang CHEN
- Publication Type:Journal Article
- Keywords:
Cerebrospinal fluid replacement;
Amphotericin B;
Cryptococcal neoformans meningitis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the curative effect of cerebrospinal fluid replacement combining intravenous drips and intrathecal injection of amphotericin B in the treatment of cryptococcal neoformans meningitis(CNM for short).Methods 28 CNM patients were randomly divided into two groups.Group A was the treatment group,and the treatment method was cerebrospinal fluid replacement combining intravenous drips and intrathecal injection of amphotericin B.Group B was the control group,and the treatment method was only intravenous drips and intrathecal injection of arnphotericin B.The period of treatment was 16 weeks.The curative effect was assessed in terms of symptoms,physical features,CSF routine examination,CSF cultivation and smear examination.Results The cura- tive effect of treatment group was better than that of the control group.There were remarkable differences between these two groups(P
