Effects of propofol on potassium currents in pulmonary artery smooth muscles of rats
- VernacularTitle:异丙酚对大鼠肺动脉平滑肌细胞钾通道电流的影响
- Author:
Yuge JIANG
;
Longhe XU
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
propofol;
potassium channels;
smooth muscle;
blood vessel;
pulmonary artery
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effects of propofol on potassium currents in pulmonary artery smooth muscle cells of normotensive and hypertensive rats. METHODS: The effects of propofol on potassium currents in smooth muscle cells derived from normotensive and hypertensive rats pulmonary arteries were observed by patch clamp technique (whole cell recording) after application of the drug in the bath. RESULTS: The potassium current-voltage curves (I-V curves) of smooth muscle cells derived from normotensive and pulmonary hypertensive rats pulmonary arteries were up-ward shifted by propofol (50, 100 ?mol/L). Compared with control group, within 5 minutes after application of the drug, the current amplitude could increase to (121?11)%, (113?5)% (P
