Study of probe substrate specificity for human cytochrome P450 isoenzymes
- VernacularTitle:人细胞色素P450同工酶探针底物特异性的研究进展
- Author:
Yu GUO
;
Hui WANG
- Publication Type:Journal Article
- Keywords:
cytochrome P450;
probe substrate;
specificity
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Analysis of metabolic activities of cytochrome P450 isoenzyme is a crucial index to study drug/toxicant metabolism, drug-drug interaction, polymorphism and et al. Due to this practice, it is important to use the proper probe substrate and to conduct the experiment under optimal conditions. The validation information in literatures on the most common and newest in vitro probe substrates have been reviewed.
