Effects of prenatal ethanol exposure on the neuronal number in visual cortex of off spring mouse
- VernacularTitle:妊娠期接触酒精对子鼠视皮质神经元数量的影响
- Author:
Qiying JIANG
;
Yanqiu HU
;
Ping WU
;
Xiangshu CHENG
;
Jinbo DENG
- Publication Type:Journal Article
- Keywords:
alcohol;
FAS;
neuron density;
visual cortex;
mouse
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study ethanol-induced changes in the development and neuronal number of visual cortex in C57BL /6 mice. Methods Female mice were fed with ethanol during pregnancy . The neuron density (ND) and cortical thickness (CT) in visual cortex of off spring mice were measured at either P0, P7 and P14 with hematoxylin and eosin (H.E) and Nissl staining. Results Embryonic death and malformationswere found in the ethanol-treated groups. Malformations, such as microcephaly,anencephaly and myeloschisis with spinabifida, etc were found in late-term embryos. The malformation rate was 12%. Compared with control group, the development of visual cortex in ethanol-treated groups was delayed, and its lamination was in disorder. The neuron polarity was disturbed. Neuron loss was found after ethanol exposure. At various ages, the neuron density in ethanol-treated groups was lower than that in control group(P
