Effects of BCPT on the expressions of cerebral cortex BDNF and Bax and the ultrastructure of hippocampus of rats treated with chronic unpredictable stress
- VernacularTitle:BCPT对CUS大鼠大脑皮质BDNF、Bax及海马超微结构的影响
- Author:
Yanyan YIN
;
Chunru LI
;
Hongwei KAN
;
Lifang ZHENG
;
Liang MING
- Publication Type:Journal Article
- Keywords:
paecilomyces tenuipes;
chronic stress;
BDNF;
Bax
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim Exploration of the effects of bioactive compound from paecilomyces tenuipes (BCPT) on the behavior, ultrastructure of hippocampus, and expressions of BDNF and Bax of cerebral cortex in CUS rats. Methods The depression model rat was induced by chronic unpredictable stress(CUS). The Open field test was used to observe the behavior of CUS rats. The expressions of BDNF and Bax of cerebral cortex were studied using immunohistochemical method, and average optical density of cortical neuron was calculated by image analysis. Morphology of hippocampus was observed by transmission electron microscope. Results Compared with model group, BCPT could obviously increase the activity of ambulation and rearing and the number of positive neuron of BDNF, decrease the number of positive neuron of Bax, and effectively prevent pathological damage induced by chronic unpredictable stress. Conclusion BCPT may exhibit the effects of antidepression, up-regulate the expression of BDNF, down-regulate the expression of Bax, and improve of the ultrastructure of hippocampus.
