Effect of the total saponins of Rubus parvifolius on the intracellular free calcium in ischemic hippocampal neurons
- VernacularTitle:茅莓总皂苷对大鼠海马神经元细胞缺氧损伤后胞内钙超载的影响
- Author:
Jisheng WANG
;
Zongyin QIU
;
Huizhi LI
;
Chenglin ZHOU
- Publication Type:Journal Article
- Keywords:
the total saponins of Rubus parvifolius(TSRP);
hippocampus neurons;
ischemia;
intracellular calcium
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effect of the total saponins of Rubus parvifolius(TSRP)on the intracellular free calcium levels in ischemic hippocampus neurons.Methods The cytosolic free calcium concentration in ischemic hippocampal neurons was measured by using Ca2+-sensitive fluorescent probe fluo-2/AM with a laser scanning confocal microscope.Results Application of TSRP inhibited free intracellular calcium in ischemic hippocampus neurons in a concentration-dependent manner.Conclusions These results suggest that TSRP might protect hippocampus neurons via attenuating calcium overload induced by ischemia.
